• English / United States: Locke
• Japanese / Japan: コブシ
• Japanese (Romanized) / Japan: Kobushi
• Japanese (Trans) / Japan: Kobushi

Locke is a locksmith that works at Ed's shop in Jacore Town where he also trains under him as his apprentice. He took on the masked persona Master Thief Keyes (Mysterious Knuckle) in an attempt to show Ed that he'd become a very good locksmith. Locke targeted multiple locks created by Ed. He would pick and unlock them but wouldn't actually steal any of the contents inside.

Officer Jenny (Kalos) called Ed in to the jew exhibit to check on one of his locks that had been picked. He confirmed that it was his lock and that it had indeed been broken. Since none of the jewels were actually stolen, Officer Jenny (Kalos) began to believe that this was a hate crime targeting Ed. By this time, Ed had already realized that the only person that had enough knowledge to break his locks was his apprentice Locke but he didn't tell anyone at that point.

Righty had attached itself onto Bonnie as it was trying to find Locke and Lefty. Ed said he didn't have the time so Righty went off on its own to find them. After reuniting in the hotel hallway, Ed allowed Righty to stay with Bonnie for a day while they went looking for Locke and Lefty.

Locke had been followed by Team Rocket and they wanted him to unlock the door to the Pokémon Center's Poké Ball Storage Room but he found back and drove them off. Team Rocket though hit some canisters which blew up and caused the storage room to catch on fire. Nurse Joy (Kalos) told Locke that there were a lot of Pokémon in the storage room but she lost track of the key when the room caught fire, so he quickly picked the lock and started gathering the Poké Balls.

Once they found them, Righty returned to Ed to bring him to the Pokémon Center which was on fire and Locke and Lefty were trapped inside.

Undeterred by the fire and his safety, Ed charged to the storage room door which was locked and damaged by the fire. He and Locke worked together and reconciled their differences and managed to open the door to save all the Pokémon in Poké Balls that were inside the storage room. Ed told Locke that he had known that he was the Master Thief Keyes and he was welcomed to return to the locksmith shop as soon as he had atoned for his crimes. Little did Locke realize, but Ed had already talked to Officer Jenny (Kalos) and since all Locke had really done was open locks, she was only going to issue him a stern warning and he'll be released in no time at all. Ed figured this would make him learn his lesson better if he didn't tell him beforehand.